Don Mosier, MD, PhD | Rimini Road
In San Diego County, twice as many males as females are infected with the coronavirus that causes COVID-19. What is going on? Are males poorer at social distancing? Are they more likely to gather in large groups? Are they just not as smart?
These could be possible explanations, but the fact is that males have poorer immune responses than females and are more susceptible to many other infections. The biological explanation for this observation in humans and other species is that females are far more critical for reproduction success than males. The downside of the more robust immune response in women is that they are more susceptible to autoimmune diseases like lupus.
Better immunity in women does not exclude the other possible explanations; it just adds one more plausible factor.